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Hygroton
Active substance: chlortalidone
Strengths: 25 mg, 50 mg
Shelf life: long
Pack sizes: 50, 100 pcs
Indications: arterial hypertension; oedema of various origins (chronic heart failure, nephrotic syndrome, portal hypertension syndrome in liver cirrhosis); diabetes insipidus
Synonyms: oxodolin
Instructions for use: Hygroton
Brief reference information compiled from official German sources (Gelbe Liste, Fachinfo, Apotheken Umschau). It does not replace a doctor’s consultation or the package insert. This is a prescription medicine — use it only as directed by a doctor.
Active substance
Chlortalidone (Chlortalidon) — a long-acting thiazide-like diuretic
Available forms
- 25 mg tablets (Hygroton 25 mg Tabletten), packs of 20, 25, 50 and 100 tablets; the tablet can be divided into equal doses
- 50 mg tablets (Hygroton 50 mg Tabletten)
- Manufacturer / marketing authorisation holder in Germany: Trommsdorff GmbH & Co. KG
Indications
- Arterial hypertension (high blood pressure)
- Oedema of cardiac, hepatic and renal origin
- Marked (manifest) heart failure
- Nephrogenic diabetes insipidus (when other medicines are unsuitable)
How to take
In hypertension: per the instructions a starting dose of 12.5–50 mg of chlortalidone once a day (in the morning, with breakfast), maintenance dose — 12.5–25 mg per day. In oedema: a starting dose of 50–100 mg/day, maintenance 25–50 mg/day; the maximum daily dose is 200 mg (higher doses do not increase the effect). The exact dose and duration of treatment are determined only by the doctor.
Contraindications
- Hypersensitivity to chlortalidone, thiazides and sulfonamide derivatives
- Anuria, severe renal failure (creatinine clearance <30 ml/min), glomerulonephritis
- Severe hepatic impairment
- Treatment-resistant hypokalaemia, severe hyponatraemia, hypercalcaemia
- Symptomatic hyperuricaemia (gout)
- Pregnancy (use is contraindicated), breastfeeding (must not be used while breastfeeding — or breastfeeding should be stopped)
- Children and adolescents under 18 years of age
Possible side effects
- Hypokalaemia (decreased potassium — very common) and other electrolyte disturbances
- Hyperuricaemia — gout attacks may occur in predisposed individuals
- Increased cholesterol and triglyceride levels
- Lowering of blood pressure, dizziness
- Gastrointestinal disturbances (nausea, vomiting)
- Muscle weakness
- Increased skin sensitivity to ultraviolet light
Special precautions
- Prescription medicine in Germany (verschreibungspflichtig)
- Regular monitoring of blood electrolytes is required — primarily potassium, sodium, magnesium and calcium
- Special monitoring in patients with diabetes mellitus and gout
- During treatment, adequate fluid intake and potassium-rich foods are recommended; avoid liquorice
- Contains lactose (lactose monohydrate 32.58 mg in the 25 mg tablet)
Sources: www.gelbe-liste.de, www.gelbe-liste.de, www.gelbe-liste.de, www.apotheken-umschau.de
